DrAutoimmuneGirl | Donna Mazzola

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Pharm D, Functional Medicine, Healing my Hashimotos, Balancing #Nutrition and #Medicine

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We talk so much about Probiotics and their importance, but what about Prebiotics- both are necessary to support gut health!!⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ Unfortunately, the standard American diet doesn't feed the good bacteria and help them grow, but rather triggers inflammation, further disrupting the balance of good and bad bacteria⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ It’s important to help beneficial bacteria flourish by ingesting probiotic foods or supplements that contain the “good” GI bacteria such as bifidobacteria and lactobacillus species, and by consuming the high soluble fiber foods or prebiotic supplements that good bugs like to eat to help them grow!!⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ Check out my full blog post on my website and READ MORE on the importance of consuming BOTH and what quality supplement I personally take and recommend!!⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ LINK IN BIO!!!!⠀⠀⠀⠀⠀⠀⠀⠀⠀ __ ⠀⠀⠀⠀⠀⠀⠀⠀⠀ #functionalmedicine #functionalnutrition #functionalpharmacy #functionalmedicinedoctor #functionalmedicinecoach #functionalmedicinepractitioner #functionalnutritionist #integrativemedicine #integrativehealth #integrativenutrition #integrativewellness #integrativehealthcoach #functionalpharmacy #functionalpharmacist #integrativepharmacist #integrativepharmacy #Probiotics #probioticsupplements #Probioticskincare #probiotic #probioticos #prebiotics #prebiotic #prebioticos #prebioticfoods #guthealth #guthealing #leakygut #healyourgut

As well as a strong connection between our brain and gut, 70% of our immune system is located in the gut and needs healthy and regular food intake to support our overall health⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ There are hundreds of species of bacteria and more than 100 trillion live in our gut. ⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ Together with fungi and viruses, these bacteria make up the gut microbiome in our body⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ Our digestive system functions at its optimum when there is a balance of the good and bad gut bacteria living in it. ⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ Scientific evidence now shows that the types of food that you eat will directly determine the levels of certain bacteria in your gut, and therefore the diet and food you choose will either support and strengthen your immune system or weaken your defense system⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ Help beneficial bacteria flourish by ingesting probiotic foods or supplements that contain the “good” GI bacteria such as bifidobacteria and lactobacillus species, and by consuming the high soluble fiber foods that good bugs like to eat, called prebiotics. ⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ Prebiotics are food ingredients that selectively stimulate the growth of beneficial microorganisms already in the colon. Prebiotics feed probiotics. ⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ Takeaway:⠀⠀⠀⠀⠀⠀⠀⠀⠀ 📍probiotics/prebiotics are important⠀⠀⠀⠀⠀⠀⠀⠀⠀ 📍Polyphenols from foods balance our gut microbiota ⠀⠀⠀⠀⠀⠀⠀⠀⠀ 📍Inulin(soluble dietary fiber) maintain gut integrity⠀⠀⠀⠀⠀⠀⠀⠀⠀ ____ ⠀⠀⠀⠀⠀⠀⠀⠀⠀ #immunesystem #immunesupport #immunesystemsupport #immunebooster #immune #immunehealth #immunity #immunityboost #immunitybooster #immunebooster #guthealth #guthealthmatters #guthealing #guthealthy #guthealingiseverything #leakygut #leakygutsyndrome #leakygutdiet #ibs #healthygut #microbiome #sibo #digestivehealth #ibd #healyourgut #probiotics #bloating #candida #digestion #leakyguthealing

We’ve talked about the anti-inflammatory benefits as they relate to turmeric and curcumin, but this is exciting to hear its linked to our gut health…⠀⠀⠀⠀⠀⠀⠀⠀⠀ __⠀⠀⠀⠀⠀⠀⠀⠀⠀ A pilot study published in the Journal of Evidence-Based Integrative Medicine evaluated the effects of turmeric and curcumin on #gutmicrobiota ⠀⠀⠀⠀⠀⠀⠀⠀⠀ __⠀⠀⠀⠀⠀⠀⠀⠀⠀ Researcher gave 30 subjects either turmeric tablets, curcumin tablets, or placebo, and then evaluated changes in the subjects’ #gut microbiota, including increases in the diversity of microbiota species.⠀⠀⠀⠀⠀⠀⠀⠀⠀ __⠀⠀⠀⠀⠀⠀⠀⠀⠀ Results showed that while the placebo group saw an overall reduction of bacterial species by 15%, turmeric-treated subjects saw an increase of 7% and curcumin-treated subjects saw an increase of 69%. ⠀⠀⠀⠀⠀⠀⠀⠀⠀ __⠀⠀⠀⠀⠀⠀⠀⠀⠀ Interestingly, the patterns of microbial species abundance changes for all of these subjects in both the turmeric and curcumin treatment groups were highly similar, which suggests that curcumin was the major driver of #microbiota composition alterations⠀⠀⠀⠀⠀⠀⠀⠀⠀ __⠀⠀⠀⠀⠀⠀⠀⠀⠀ Both turmeric and curcumin altered the gut microbiota in similar ways, the researchers said. They attribute the effects of turmeric to the catabolism of polysaccharide components in the plant’s root, noting that this would make it a #prebiotic . ⠀⠀⠀⠀⠀⠀⠀⠀⠀ __⠀⠀⠀⠀⠀⠀⠀⠀⠀ Prebiotics are ingredients that are not easily digestible and are therefore able to pass through the digestive tract into the colon to feed the #microbiome there.⠀⠀⠀⠀⠀⠀⠀⠀⠀ __⠀⠀⠀⠀⠀⠀⠀⠀⠀ I place a 1 inch root in my smoothie every morning, and of course add black peppercorn to boost absorption! Comment below how you consume your turmeric….⠀⠀⠀⠀⠀⠀⠀⠀⠀ __Reference: PMID: 30088420⠀⠀⠀⠀⠀⠀⠀⠀⠀ _ #guthealth #guthealthmatters #guthealing #guthealthy #guthealingiseverything #leakygut #leakygutsyndrome #leakygutdiet #ibs #healthygut #microbiome #sibo #digestivehealth #ibd #healyourgut #probiotics #digestion #leakyguthealing #guthealthdiet #turmericbenefits #turmericlatte #curcumina

The best source of Vitamin D is the SUN!! #VitaminD is made in the skin when it's exposed to #sunlight⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ The sun is most intense at noon and when its at its highest points, this translates to the ability to make more vitamin D in less time in the sun.⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ A study in the UK found that 13 minutes of midday sunlight during the summer three times a week is enough to maintain health levels and another study demonstrated that 30 minutes midday/3 times a week is equivalent to 10,000-20,000 IU of vitamin D⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ What can impact the amount of vitamin D absorbed❓​⠀⠀⠀⠀⠀⠀⠀⠀⠀ The answer here is the color of your skin! Melanin is a pigment in your skin that determines it's color. The darker the skin, the more #melanin you have. Melanin protects the skin against damage from the sun, acting like a natural #sunscreen , but also means those with darker skin need MORE time in the sun to produce the same amount of vitamin D as their lighter skin counterpart.⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ Studies estimate that darker-skinned people may need anywhere from 30 minutes to 3 hours longer to get sufficient vitamin D⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ If you live farther away from the equator need more time in the sun, because UVB rays are absorbed by the ozone layer in these areas.⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ Bottom Line: You need to expose a sufficient amount of skin to sunlight to maintain healthy vitamin D blood levels. Wearing a tank top and shorts for 10–30 minutes 3 times per week is sufficient for lighter-skinned people, while those with darker skin may need longer. Take advantage of the SUN!!!⠀⠀⠀⠀⠀⠀⠀⠀⠀ _ ⠀⠀⠀⠀⠀⠀⠀⠀⠀ #functionalmedicine #functionalnutrition #functionalpharmacy #functionalmedicinedoctor #functionalmedicinecoach #functionalmedicinepractitioner #functionalnutritionist #integrativemedicine #integrativehealth #integrativenutrition #integrativewellness #integrativehealthcoach #functionalpharmacy #functionalpharmacist #integrativepharmacist #integrativepharmacy

Did you know that it has been identified that certain polymorphisms on the vitamin D receptor gene can modify the function of vitamin D⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ We know vitamin D plays a pivotal role in regulating the immune response and abnormal function of the Vitamin D binding protein can affect the interaction of vitamin D on immune cells⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ So we know the main source of Vitamin D is through the sun, which then has to go through 2 steps in the body to become the active 25 OHD- the main circulating form of vitamin D. The other means of getting vitamin D is through supplementation and minimally through diet.⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ The 25(OH)D binds to D Binding Protein (DBP) and is transported from the liver to other organs and tissues of the body. The majority (85–90%) of the total circulating 25(OH)D binds to DBP⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ Several studies have demonstrated that certain genetic polymorphisms of the DBP increase the risk for non-response to vitamin D supplementation even at high doses⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ This has significant clinical implications because carriers of such genotypes make current vitamin D management ineffective, putting people at risk for vitamin D deficiency⠀⠀⠀⠀⠀⠀⠀⠀⠀ _ ⠀⠀⠀⠀⠀⠀⠀⠀⠀ These studies suggest that a higher dose of vitamin D may be needed to achieve sufficient levels because patients with these #genetic polymorphisms have a less efficient response to vitamin D supplementation⠀⠀⠀⠀⠀⠀⠀⠀⠀ _⠀⠀⠀⠀⠀⠀⠀⠀⠀ This is yet another reason why you should get your levels checked if you are supplementing and consider genetic testing if your levels are not improving! ⠀⠀⠀⠀⠀⠀⠀⠀⠀ _ ⠀⠀⠀⠀⠀⠀⠀⠀⠀ #vitamind #sunshine #vitamins #vitaminddeficiency #vitamindtherapy #vitamind3 #vitamindefiiency #vitamind3k2 #vitamind☀️​ #vitaminddeficient #epigenetics #genetics #nutrigenetics #humangenetics #genetictesting #genetictest #nutrigenomics #genomics #functionalmedicine #functionalnutrition #]#functionalpharmacy #functionalpharmacist #integrativepharmacist

☀️Several studies have shown the correlation between vitamin D deficiency and #thyroid autoimmunity AND that supplements are effective in reducing TPO-Ab among #Hashimotos patients with vitamin D deficiency ---- ✅Shin et al. revealed a negative association between 25(OH) D3 and TPO-Ab levels and further demonstrated that low 25(OH) D3 may be a possible risk factor for TPO-Ab positivity ---- ✅Kivity et al. reported that Vitamin D deficiency was associated with high levels of TgAb _ ☀️The relationship between inflammatory cytokines and autoimmune #thyroiddisease is well-known and if we consider the immunomodulator effect of Vitamin D on inflammatory responses and #autoimmunity this relationship makes sense! __ ☀️What is still unclear, however, is whether the low 25[OH ]D levels observed in Hashimotos patients are the result of the disease itself or actually part of its cause __ ☀️Vitamin D is considered to be one of the natural immune modulators and a regulator of various immune-mediated processes __ ☀️The Endocrine Society guidelines stated that daily vitamin D intakes of 1500-2000IU are needed to raise the blood level of 25(OH) D constantly above 30ng/mL __ ☀️The Institute of Medicine reported that the tolerable upper intake level, deemed as the maximum daily intake above which the potential for adverse health effects may increase after chronic use, is 4000IU per day __ ☀️Levels of 25(OH) D between 30 and 40ng/mL, that are adequate for avoiding metabolic and #autoimmune disorders, in more than 97% of the population, can be achieved by an optimal dosage of approximately 2000IU cholecalciferol daily, regardless of increased exposure to UVB __ ☀️You can also get about 1000 IU per day from 20 minutes of skin exposure in the sun WITHOUT sunscreen __ ✅Remember to consult with your doctor prior to taking #supplements , but use these references from national guidelines as a point of discussion to determine what's appropriate for YOU! ___ ✅Check out my link in bio “supplements” and you can find my favorite brand of Vitamin D! … I don't go a day without my #VitaminD do YOU?!?!? …. #vitamins #vitaminddeficiency #hashimoto #vitamind3 #hashimotosdisease #antibodies #tpo

Vitamin D has many direct and indirect effects on the immune system:⠀⠀⠀⠀⠀⠀⠀⠀⠀ 📍Promoting regulatory T cells (Tregs)⠀⠀⠀⠀⠀⠀⠀⠀⠀ 📍Inhibiting differentiation of Th1 and Th17 cells (which are elevated in autoimmunity⠀⠀⠀⠀⠀⠀⠀⠀⠀ 📍Impairing development and function of B cells⠀⠀⠀⠀⠀⠀⠀⠀⠀ 📍Stimulates antimicrobial peptides from immune cells⠀⠀⠀⠀⠀⠀⠀⠀⠀ ⠀⠀⠀⠀⠀⠀⠀⠀⠀ Another component is the GUT! ⠀⠀⠀⠀⠀⠀⠀⠀⠀ ⠀⠀⠀⠀⠀⠀⠀⠀⠀ The composition of the gut microbiome can be altered by vitamin D status/exposure⠀⠀⠀⠀⠀⠀⠀⠀⠀ ⠀⠀⠀⠀⠀⠀⠀⠀⠀ In a study that utilized endoscopy and colonoscopy biopsies in addition to stool samples, it was found that 8-weeks of vitamin D3 supplementation resulted in increased species richness in the gastric antrum, decreased Proteobacteria in the upper GI tract , and increased Bacteroidetes in the small intestine (all good things!)⠀⠀⠀⠀⠀⠀⠀⠀⠀ ⠀⠀⠀⠀⠀⠀⠀⠀⠀ So how does this all contribute to autoimmunity?⠀⠀⠀⠀⠀⠀⠀⠀⠀ ⠀⠀⠀⠀⠀⠀⠀⠀⠀ 1️⃣Vitamin D deficiency changes the microbiome, and manipulation of bacterial abundance or composition impacts disease manifestation.⠀⠀⠀⠀⠀⠀⠀⠀⠀ 2️⃣Lack of vitamin D can impair physical and functional barrier integrity (leaky gut),which leads to stimulation or inhibition of immune responses⠀⠀⠀⠀⠀⠀⠀⠀⠀ 3️⃣ Our natural, innate immunologic defenses may be compromised in the setting of vitamin D deficiency⠀⠀⠀⠀⠀⠀⠀⠀⠀ ….⠀⠀⠀⠀⠀⠀⠀⠀⠀ Moral of the story…. Have you checked your vitamin D levels? Do you take Vitamin D? Do you sit out in the sun? SHARE WITH ME BELOW!!!!⠀⠀⠀⠀⠀⠀⠀⠀⠀ ___⠀⠀⠀⠀⠀⠀⠀⠀⠀ ⠀⠀⠀⠀⠀⠀⠀⠀⠀ ⠀⠀⠀⠀⠀⠀⠀⠀⠀ ⠀⠀⠀⠀⠀⠀⠀⠀⠀ ⠀⠀⠀⠀⠀⠀⠀⠀⠀ #vitamind #sunshine #vitamins #vitaminddeficiency #vitamindtherapy #vitamind3 #vitamindefiiency #vitamind3k2 #vitamind☀️​ #vitaminddeficient #autoimmunedisease #autoimmunewarrior #autoimmuneawareness #autoimmune #autoimmunewellness #autoimmunediseases #autoimmunedisorder #autoimmunediseasewarrior #autoimmunelife #autoimmuneillness

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